TLR4 and neoplasm: Unexpectedly, activation of the Toll signalling pathway in the fat body of tumour-bearing animals could be prevented by knocking-down the Toll ligand Spaetzle (spz) in haemocytes or by removing Egr from tumours, suggesting that Egr produced by the tumour promotes Spz production by haemocytes, which in turn activates the Toll pathway in the fat body [46].