AKT1 and hepatocellular carcinoma: Moreover, OXCT1 expression in HCC cells is dependent on the mTORC2-AKT-SP1 signaling axis and induction of ketolysis by OXCT1, by supplying cells with ATP, suppresses AMPK activation upon nutrient starvation, avoiding the deleterious excessive autophagy and promoting HCC cell survival and proliferation (29).