FOXP2 and Familial prostate cancer: With regards to oncogenesis mechanism, it should be noted that the FOXP2 transcript is a bona fide target of miR-190, a microRNA lying within an intron of, and concomitantly expressed with, the cytoskeleton-associated protein TALIN2 (TLN2) - with both genes being down-regulated in advanced prostate cancer [143].