SHH and basal cell carcinoma: i) The SMO (SMOOTHENED gene), at 7q32, a frizzled-class receptor belonging to the SONIC HEDGEHOG (SHH) pathway, associated with oncogenic conditions including basal cell carcinoma, malignant glioma, medulloblastoma, leukemia, and cancers of the breast, lung, pancreas, and prostate [26].