LEF1 and cancer: Additionally, LEF1 and MET, tightly related to the Wnt/b-catenin signaling pathway [161], are strongly associated to FOXP2 (for LEF1 see section 1.1.3.2) (for MET see sections 1.1.1, 1.1.2.2, 5.2.2 and 5.3.3), and both of them have been proposed as biomarkers for prognosis and targets for cancer treatment [41] [24].