Further, tribody [(HER2)2xCD16] alone or control constructs such as tribody [(HER2)2xCD89] which has no specificity for NK cells or γδ T cells or tribody [(CD20)2xCD16] targeting CD20 being not expressed on the applied tumor cells, did not trigger target cell lysis (Figure S2 in Supplementary Material). Here, ERBB2 is linked to neoplasm.