Regarding the role of γδ T cells in the uptake of antigens via Ab-opsonization and CD16 and their possibility to cross-present antigens to αβ T cells after their activation (33, 73), we can speculate that tumor antigens could be taken up by γδ T cells and presented to αβ T cells after activation based on our observation that PAg and tribody [(HER2)2xCD16] stimulation induce a γδ T-APC phenotype. Here, ERBB2 is linked to neoplasm.