Our results clearly demonstrate that γδ T cells within PBL or TIL can be activated via a combined stimulation by their selective antigens plus IL-2 plus tribody [(HER2)2xCD16] to effectively lyse allogeneic as well as autologous tumor cells via the release of granzyme B. In general, cytotoxic γδ T cells often release granzymes out of their cytolytic granules after their activation by bsAb, which could be an advantage regarding the aspect that several tumor cells are almost resistant to the CD95- or TRAILR-induced cell death (38, 47). This evidence concerns the gene FAS and neoplasm.