In line with and highlighting our findings, Chirco et al. have recently shown that mCRP is the more abundant form of CRP in human RPE-choroid, and that mCRP levels are elevated in individuals with the high-risk CFH geno-type (91), which could thus sustain chronic inflammation contributing to the progression of AMD in CFHH402 individuals. The gene discussed is CRP; the disease is age-related macular degeneration.