The strongest genetic risk factor for AMD known to date is a common polymorphism in the CFH gene (c.1277T > C, p.Tyr402His); the CFH p.Tyr402His variant (in following termed CFHH402) increases the risk for AMD approximately twofold to fourfold for heterozygous and fivefold to sevenfold for homozygous individuals (5, 16, 46). The gene discussed is CFH; the disease is age-related macular degeneration.