It has been well studied that polymorphisms in the TNFR2 gene have a strong correlation with a wide variety of autoimmune diseases, e.g., RA (40–42), Crohn’s disease (43), systemic lupus erythematosus (44), ankylosing spondylitis (AS) (45), inflammatory bowel diseases (IBD) (46), and ulcerative colitis and scleroderma (47). The gene discussed is TNFRSF1B; the disease is inflammatory bowel disease.