The remarkable control and clearance of virus from lymphoid follicles in natural hosts is associated with multiple differences compared to pathogenic infection: (1) LN architecture is preserved; (2) inflammation is controlled; (3) FDC network is maintained intact; (4) rapid mobilization of innate antiviral responses; (5) viral replication is strongly controlled; (6) TFH are particularly spared from virus; (7) NK cells migrate into follicles; and (8) high IL-15 production within follicles (Table 1). Here, IL15 is linked to infection.