In systemic lupus erythematosus (SLE), both T cells (21) and mesenchymatous stem cells (22) secrete high levels of IFN-I that are associated with mitochondrial dysfunctions, including enhanced mtROS production, and that are reduced by MAVS silencing (22) and ROS inhibition (21). The gene discussed is MAVS; the disease is systemic lupus erythematosus.