As with the combination of RT and anti-CTLA4, treatment with FTY-720 prior to tumor implantation prevented tumor cure by the combination of RT with anti-PD1 (Logrank survival RT vs RT + anti-PD1 p < 0.05; RT vs RT + anti-PD1 + FTY-720 Not significant) (Fig. 2e). The gene discussed is CTLA4; the disease is neoplasm.