Administration of a single dose of FTY-720 24 hours prior to Panc02-SIY tumor implantation significantly decreased antigen-specific responses detectable in the peripheral blood (Fig. 2ciii) consistent with the effect of FTY-720 on subcutaneous vaccination with DEC-205-Ova plus anti-CD40 and on systemic vaccination with attenuated L. monocytogenes (Fig. 2civ-v). This evidence concerns the gene CD40 and neoplasm.