Treatment prior to tumor implantation entirely blocked the efficacy of anti-CTLA4 plus RT treatment (Fig. 2di-ii) while treatment with FTY-720 immediately prior to RT had no effect – tumors in these mice were effectively rejected by anti-CTLA4 plus RT (Logrank survival d-1 vs d13 FTY-720 p < 0.05) (Fig. 2diii-iv). The gene discussed is CTLA4; the disease is neoplasm.