This association remained significant for patients with high tHcy levels (fourth quartile) as compared to patients with low tHcy levels (first quartile), even after adjusting for age, sex, smoking status, LDL-C level, hsCRP level, and ApoB/ApoAI ratio and the presence of hypertension, type 2 diabetes mellitus, coronary artery disease, and obesity (adjusted HR: 1.76; 95% CI: 1.11–3.08; p = 0.031) (Table 5). The gene discussed is APOA1; the disease is obesity due to melanocortin 4 receptor deficiency.