GNMT and urogenital neoplasm: In our Gnmt genetically-modified mouse models, we were able to induce AA nephropathy in a C57BL/6 background which was similar to the human histopathology40,41 and demostrated that GNMT protected mice from AAI-induced kidney injury by increasing CAR/PXR and CYP3A44/3A41 transcriptions and decreasing NRF2/NQO1 transcriptions in female mouse hepatocytes.