In NOD-SCID mice xenotransplanted with human CLL cells without del(17p) (no p53 mutations) there was a statistically significant reduction of CD45+/CD19+/ROR1+ cells in the spleen (flow cytometry) at a high dose of KAN0439834 but less pronounced at a low dose. The gene discussed is ROR1; the disease is B-cell chronic lymphocytic leukemia.