Our results show that the expression of BRD7 is associated with that of ER in breast cancer tissues shown in Table 2, which fits with the finding that depletion of BRD7 results in loss of ERα expression in breast cancer cells47, while ERα signaling pathway has also been reported to directly regulate HIF1α expression9, appearing BRD7 could positively regulate HIF1α through activation of the ERα signaling pathway. Here, ESR1 is linked to breast cancer.