A Bayesian network analysis containing these risk loci as well as gene expression data identified an IBD sub-network that includes several genes (e.g., IL10, NOD2, HCK and WAS) that are highly enriched in bone-marrow-derived macrophages (BMDMs) and point to a possible role for this IBD sub-network in regulating anti-inflammatory macrophage development and/or function1. Here, NOD2 is linked to inflammatory bowel disease.