L1CAM and systemic lupus erythematosus: In this cross-population meta-analysis of three GWAS datasets and further replication in three additional cohorts, with a total of 7995 cases and 14,601 healthy controls, we successfully identified a novel variant (rs13440883, Pmeta = 7.53 × 10− 9, ORmeta = 1.16) within GPR173, as well as a potential independent signal (rs5987175, P = 6.55 × 10− 3, upon adjusting for the effect of rs17422, rs2071128, and rs1059702 together in Asians) within LCA10 of the L1CAM-MECP2 region on chromosome X as being associated with SLE.