Interestingly, treatment of multiple sclerosis patients with the FDA-approved therapeutic agents type-I IFN, glatiramer acetate or natalizumab (https://www.ncbi.nlm.nih.gov/books/NBK294198/table/introduction.t1/#__NBK294198_dtls__) was shown to affect the expression of IL-1Ra and/or the production of IL-1β [10, 23, 52, 53]. Here, IL1B is linked to multiple sclerosis.