Importantly, we firstly discovered the bioactive components of propolis on the protection effects in ox-LDL induced HUVECs injury were not determined by a single compound, and provided new insights to elucidate the mechanisms of propolis on chronic inflammation including atherosclerosis by activating PI3K/Akt/mTOR signaling pathway, inhibiting LOX-1/p38 MAPK level, depressing ROS production and protecting MMP to inhibit apoptosis and autophagy. The gene discussed is AKT1; the disease is atherosclerosis.