Among the common upregulated genes was the inhibitor of hedgehog signaling TULP3 [45], which was significantly overexpressed in all CIN knockdown cell lines (Fig. 6c, adjusted p-values calculated by DESeq2, · = p < 0.1, * = p < 0.05, ** = p < 0.01, *** = p < 0.0001). The gene discussed is TULP3; the disease is cervical squamous intraepithelial neoplasia.