Finally, as turnover of p-cofilin can be more important than absolute levels of the phosphorylated protein and altered absolute p-cofilin levels are not present in all cell lines cultured in serum after CIN deregulation [8], we tested if inhibitors of the upstream kinases ROCK1/2 or LIMK1/2 are able to sensitize the cell lines NCH421k and NCH644 to chemotherapeutic agents. The gene discussed is CFL1; the disease is cervical squamous intraepithelial neoplasia.