IRF4 and plasma cell myeloma: For example, super-enhancer-associated genes include IRF4 and MYC in multiple myeloma [40], PAX5, MYC, and IRF4 in diffuse large B-cell lymphoma [41], MYCN and ALK in neuroblastoma [42], and CDK6, MYC, and EGFR in glioblastoma [17,20].