Preliminary data from our group showed that murine models of NAFLD based on a high fat diet (HFD) present dysfunction of this axis, with lower pituitary secretion of growth hormone (GH) and a reduced response to growth hormone releasing hormone (GHRH); and in the liver, a reduced expression of insulin-like growth factor-1 (IGF-1) at baseline and after GH stimulation. The gene discussed is GH1; the disease is metabolic dysfunction-associated steatotic liver disease.