On the other hand, animal studies reveal that FGF-21 deletion aggravates diabetes-induced aortic remodeling and inflammation in type 1 diabetic mice [51] and Apo E(−/−) mice [52]; the blockage of endogenous angiotensin remarkably enhances contents of lipids and macrophages and decreases contents of VSMCs and collagens in aortic lesions in Apo E(−/−) mice [53]. Here, APOE is linked to diabetes mellitus.