LMP1 is able to transform B cells and rat fibroblasts in vitro [3] and causes morphological alterations in epithelial cells by activating a variety of cell signalling pathways commonly deregulated in cancer, including NF-κB1 and KF-κB2, ERK-MAPK, PI3K/Akt, JNK/SAP, p38-MAPK and activin A/TGFβ [6,7]. The gene discussed is NFKB1; the disease is cancer.