TGFB1 and neoplasm: In addition to being stimulated by TGFβ signalling, various integrins (including αvβ3, αvβ5, αvβ6 and several β1 integrins) are able to bind latent TGFβ embedded within the ECM in the tumour microenvironment, thus activating TGFβ signalling and subsequently Src/FAK complex formation.