The role of the JAK/STAT pathway was confirmed in flies mutant for the JAK kinase Hopscotch, that showed higher mortality and increased viral titers after DCV and CrPV dicistrovirus infection, but not after infection with other RNA viruses (VSV, FHV, DXV, SINV) and the DNA virus IIV-6 [34]. This evidence concerns the gene SOAT1 and infection.