Another study showed that vascular permeability was lower in knockout mice with concomitant C1-INH and bradykinin receptor B2 (BDKRB2) deficiencies than in mice with only C1-INH deficiency, demonstrating that the bradykinin/BDKRB2 pathway plays an important role in angioedema 46. The gene discussed is BDKRB2; the disease is angioedema.