PLOD1 and metabolic syndrome: While the use of testosterone propionate (TP) to prenatally androgenize rats has been reported to produce limited PCOS-like features in animals [58], PNA rat models using T or DHT exposure between days 16–19 of gestation exhibit anovulation and irregular estrous cycles, elevated LH and increased frequency of LH secretion, polycystic ovaries, greater number of preantral and antral follicles, fewer preovulatory follicles and corpora lutea, elevated T and estradiol, dyslipidemia, greater body weight, and insulin resistance [29, 30, 34, 35, 55, 58–60].