In silico predictions suggested that they were involved in several important biological processes and functional pathways associated with AF, such as TGF-beta 1 and Insulin-like growth factor 1 (IGF-1) signaling, proliferation and cellular adhesion (MAPkinase and AKT pathways), and circadian clock/synchronisation of circadian rhythmicity, but also in RNA-mediated gene silencing (i. e. AGO/EIF2C proteins) and miRNA machinery (i. e. TNRC6 proteins), further suggesting that alteration of miRNAs in LA would in fact perturbate the whole miRNome. This evidence concerns the gene AKT1 and atrial fibrillation.