NPPB and congestive heart failure: The secondary objectives were 1) to evaluate the effect of ACT chemotherapy on the QTdc and DTpTe values; 2) to assess any changes in cardio-specific biomarkers, such as troponin and B-type natriuretic peptide (BNP); and 3) to assess the clinical manifestations of cardiotoxicity, including the presence of cardiac arrhythmias, congestive heart failure (CHF), angina and cardiovascular death in patients with breast neoplasms who were undergoing ACT chemotherapy.