Among high M3 CF-PWV patients (>10.6 m/s), a significant CF-PWV improvement was noticed between M3 and M12 (-0.5 m/s, p = 0.03), despite a similar MBP and no significant cv score or mGFR variation (p = 0.61 and 0.42 respectively). This evidence concerns the gene MBP and cystic fibrosis.