TRPM8 and migraine disorder: The very specific tissue expression of the gene makes it extremely challenging to test this prediction experimentally, but a regulatory function fits well the location of the SNP, which sits ~1 kb upstream of TRPM8. We note that no neighboring SNP in high linkage disequilibrium (LD) shows stronger evidence of association with migraine [24] or functionality (S2 Fig) than rs10166942.