Hair graying can be elicited through a number of mechanisms—disrupting the signaling pathways associated with the Kit receptor, Notch receptor, Endothelin receptor type B, Raf kinase, Transforming growth factor beta, or Wnt [4–11]; loss of anti-apoptotic control [12,13]; melanocyte-specific dysregulation of chromatin remodeling complexes [14]; exposure to genotoxic stress [15,16]; changes in sex determining region Y-box 10 (SOX10) or MITF-mediated transcriptional regulation [13,17]; vitiligo-like T-cell–mediated destruction of melanocytes [18]; and aging itself [13]. The gene discussed is MITF; the disease is vitiligo.