The findings from this small‐scale, cross‐sectional study (43 cancers; 38 controls) suggested that consideration of multidimensional relationship (MDR) of the IGF system might yield additional insight compared with single components alone, as free IGF levels depend on total IGF and IGFBP concentrations as well as IGFBP‐protease activity 1, 2. Here, IGF1 is linked to cancer.