SOX2 and liver cancer: Specifically, the proliferation rate was markedly higher in liver cancer cells treated with SHH than the control (Figure 5C); the sphere formation (Figure 5D) and migration capacity (Figure 5E) of CD90+ liver cancer cells were significantly enhanced by SHH treatment; and the expression of CD90 and SOX2 genes was remarkably increased by SHH treatment in liver cancer cells expressing CD90 (Figure 5A,B and Figure S2).