REN and obesity due to melanocortin 4 receptor deficiency: For example, BMI may be linked to low-grade inflammation and the “obesity paradox” risk phenomenon [17, 18]; while LVEF may be associated to myocardial injury, ventricular arrhytmia, pump failure with activation of renin-angiotensin-aldosterone and adrenergic systems leading to negative myocardial remodeling and deterioration in contractile function [15] and coronary severity may influence due to the degree of vascular damage, although the relation between coronary stenosis with plaque stability or future MACE’s is still debatable [16].