Enoxolone, the aglycone of the glycyrrhizic acid, is used to prevent liver carcinogenesis in patients with chronic hepatitis C. Glycyrrhizin was reported to influence the renal functions by modulating AQP2 and AQP3, two AQPs expressed in the principal cells of the renal distal tubules and collecting ducts where they mediate the antidiuretic hormone (ADH)-induced water reabsorption (Kang et al., 2003). This evidence concerns the gene AVP and digestive system neoplasm.