Mucin 16 (also known as CA125) and WAF four-disulfide core domain protein 2 (also known as HE4) are the only clinically-approved serum markers of ovarian cancer and have been shown to perform better for serous OvCa compared to other subtypes (Leunget al., 2016;Shenet al., 2017). Here, WFDC2 is linked to ovarian carcinoma.