CASP4 and hepatocellular carcinoma: In particular, the levels of the circulating caspase-4 were significantly lower in the plasma of endometrial carcinoma (KE, n = 12), ovarian carcinoma (KO, n = 12), colon carcinoma (K colon, n = 16), liver carcinoma (K liver, n = 5), bladder carcinoma (K bladder, n = 6) and melanoma (n = 9) (Figure 2A).