In our cohort we also observed this association between SRSF2 and TET2. The role of SRSF2 mutations in MDS is not yet well understood; while in some studies, these mutations have been associated with worse OS and a higher rate of transformation to AML [30], other groups have demonstrated that SRSF2 mutations do not have impact on OS [31]. This evidence concerns the gene TET2 and myelodysplastic syndrome.