HPSE and hepatocellular carcinoma: Strikingly, the growth of tumor xenografts produced by HCC-827 (Figure 1F, p < 0.0002), HTB-182 and A549 (Supplementary Figure 2A, B; p < 0.0001 and p < 0.003, respectively) cells was halted (Figure 1F) or reduced 3–4 fold by PG545, altogether implying that heparanase promotes lung cancer progression and that heparanase inhibitors can be applied to attenuate tumor growth.