Therefore, we conducted a protein analysis on mesothelioma cell lines after Kp-10 treatment and we were able to demonstrate that such treatment determines the up-regulation of E-cadherin, a key cell adhesion molecule, and the loss of typical mesenchymal markers such as Vimentin, Snail and Slug suggesting that cells, under the effect of Kp-10, retain the epithelial phenotype by inhibiting the EMT. This evidence concerns the gene CDH1 and mesothelioma.