First of all, we checked the presence of transcripts and proteins of KiSS1 and its coupled receptor, GPR54, in mesothelioma cell lines H2452, H28 and MSTO observing a prevalence of expression levels in H2452 and H28 lines, epithelial and sarcomatoid mesothelioma, respectively. The gene discussed is KISS1R; the disease is mesothelioma.