For example, Wiemels et al. were able to detect the t(12;21) chromosomal translocation resulting into TEL-AML1 in 9/12 neonatal blood spots (Guthrie cards) from children with TEL-AML1+ B-cell precursor acute lymphoblastic leukemia (B-ALL) [3]. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.