For example, Wiemels et al. were able to detect the t(12;21) chromosomal translocation resulting into TEL-AML1 in 9/12 neonatal blood spots (Guthrie cards) from children with TEL-AML1+ B-cell precursor acute lymphoblastic leukemia (B-ALL) [3]. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.