Further risk of false positive results stem from the identification of variants identified from somatic tissue, i.e., true somatic mutations misidentified as deleterious (inherited) germline variants in such genes as BRCA1, BRCA2, and ATM. In 10 genes associated with germline risk for familial disease (the inherited risk gene panel), true somatic mutations in germline genes were discovered in 10 lung cancer patients (11 variants) and 101 total patients (118 variants) when using the tumor-only sequencing approach. The gene discussed is BRCA1; the disease is neoplasm.