LAG3 and neoplasm: Expression of MHC II by MB is unusual as this molecule is usually a feature of dendritic cells and other APCs indicating that this tumor may be directly inhibiting anti-tumor immune responses by masquerading as an inhibitory APC [24, 50] MHC II expression may also indicate a role for the immune checkpoint molecule, lymphocyte activating gene-3 (LAG-3) in MB whose primary ligand is MHC II.