In our study, the suppression of PPP2R3A regulatory subunit of PP2A, specifically the PR72 isoform of PPP2R3A, through increased miR-652 expression in prostate cancer cells, correlated with activation of the ERK-1/2, AKT in both PC3 and LNCaP cells, and activation of Wnt signalling pathways, together with inhibition of the p53 and p21 in LNCaP cells. The gene discussed is TP53; the disease is prostate cancer.