In our study, the suppression of PPP2R3A regulatory subunit of PP2A, specifically the PR72 isoform of PPP2R3A, through increased miR-652 expression in prostate cancer cells, correlated with activation of the ERK-1/2, AKT in both PC3 and LNCaP cells, and activation of Wnt signalling pathways, together with inhibition of the p53 and p21 in LNCaP cells. Here, PPP2R3A is linked to Familial prostate cancer.