In prostate cancer, conditioned culture medium, from bone marrow stromal cells, decreased the proliferation of and induced apoptosis in LNCaP and C4-2B, but not PC3 cells [29], CAFs induced apoptosis in gastric cancer cells [30], and human mesenchymal stem/stromal cells and CAFs, activated to express tumour necrosis factor (TNF)-alpha-related apoptosis-inducing ligand (TRAIL), induced apoptosis in breast cancer cells [31, 32]. This evidence concerns the gene TNFSF10 and Familial prostate cancer.