Similarly, in castrated, immunodeficient NOD-SCID mice sub-renally grafted with a combination of human-derived primary prostate cancer tissue and either PShTert-AR or PShTert myofibroblasts, we found that grafts with PShTert-AR showed significantly more apoptosis in the cancer cells than grafts with PShTert [5]. Here, AR is linked to Familial prostate cancer.