Based on these data, we then investigated the prognostic value of DNMT3A and DOT1L protein expression in samples from 31 patients with DLBCL treated with R-CHOP or R-CHOP-like therapy and in five non-neoplastic tissues (two reactive lymph nodes and three tonsil specimens) as control (all from the Pathology Department, Montpellier University Hospital, France). The gene discussed is DNMT3A; the disease is diffuse large B-cell lymphoma.