To this aim, we split the training cohort (Lenz R-CHOP cohort, n = 233 patients) in four groups according to the tumor expression of these three genes: group 1 (low DNMT3A, DOT1L and SETD8 expression), group 2 (high expression of one of the three genes), group 3 (high expression of two of the three genes), and group 4 (high expression of all three genes). Here, KMT5A is linked to neoplasm.