We then validated the EpiScore prognostic value in two independent cohorts of patients with DLBCL (Melnick cohort: n = 69 patients treated with R-CHOP, P = 4.4E-5, n = 69; and Lenz CHOP cohort: n = 181 patients, P = 7.8E-6) (Figure 6C and 6D). Here, DDIT3 is linked to diffuse large B-cell lymphoma.