CD8A and glioblastoma: In addition, CD4 was downregulated in the Th2Low subgroup (Figure 5A), whereas CD8 was not included in the 98 differentially expressed genes in the Th2Low subgroup, suggesting that CD8 expression and/or CD8+ cells may not have been correlated with the low Th2 balance in the GBM patients and their long overall survivals.