On the other hand, all 98 differentially expressed genes in the Th2Low subgroup showed the same magnitudes of downregulation as those in the Th2High subgroup, but not in both the CD274Low and PDCD1Low subgroups, when compared to their corresponding high subgroups (Figure 5A), suggesting that the Th2 score is prior to CD274 and PDCD1 expression for prognostic prediction in GBM. This evidence concerns the gene CD274 and glioblastoma.