Sorting and assembly machinery component 50 homolog participates in mitochondrial respiratory chain complexes assembly and mitochondrial morphology. In apoptotic cells, mitochondrial fission requires the cytoplasmic dynamin-related protein, DRP1, a GTPase protein responsible for mitochondrial division that translocates to the nucleus [98]. DRP1 is involved in apoptosis in prostate cancer cells [42]. The gene discussed is DNM1L; the disease is prostate carcinoma.