Additionally, we evaluated the correlation between the distribution of NOTCH1 and NUMB throughout serial histological sections and found to be statistically significant in ICC but not in CIN (r = 0.226, P = 0.116 in CIN vs. r = 0.306, P = 0.002 in ICC) (Supplementary Figures 2 and 3). Here, NUMB is linked to cervical squamous intraepithelial neoplasia.