ADAM10 and hepatocellular carcinoma: Additionally, DSF did not upregulate MICA expression in normal human hepatocytes, with very low protein levels of MICA and ADAM10 in contrast to HCC cells [8, 17, 18], or interfere with NKG2D expression in NK cells (Figure 3A and 3B), which indicated selective enhancement of mMICA levels in HCC cells and efficient transduction of signaling for NK cell activation.