The mTOR inhibitor, temsirolimus (Torisel®), has been approved for first-line treatment of RCC patients with poor-prognosis, whereas the oral mTOR-inhibitor RAD001, (everolimus; Afinitor®), is recommended for patients with advanced progressive RCC or for patients with failed VEGF-targeted therapy. The gene discussed is MTOR; the disease is renal cell carcinoma.